1auv
From Proteopedia
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'''STRUCTURE OF THE C DOMAIN OF SYNAPSIN IA FROM BOVINE BRAIN''' | '''STRUCTURE OF THE C DOMAIN OF SYNAPSIN IA FROM BOVINE BRAIN''' | ||
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[[Category: Esser, L.]] | [[Category: Esser, L.]] | ||
[[Category: Wang, C.]] | [[Category: Wang, C.]] | ||
| - | [[Category: | + | [[Category: Phosphorylation]] |
| - | [[Category: | + | [[Category: Synapse]] |
| - | [[Category: | + | [[Category: Synapsin ia c-domain]] |
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Revision as of 07:43, 2 May 2008
STRUCTURE OF THE C DOMAIN OF SYNAPSIN IA FROM BOVINE BRAIN
Overview
Synapsins are abundant synaptic vesicle proteins with an essential regulatory function in the nerve terminal. We determined the crystal structure of a fragment (synC) consisting of residues 110-420 of bovine synapsin I; synC coincides with the large middle domain (C-domain), the most conserved domain of synapsins. SynC molecules are folded into compact domains and form closely associated dimers. SynC monomers are strikingly similar in structure to a family of ATP-utilizing enzymes, which includes glutathione synthetase and D-alanine:D-alanine ligase. SynC binds ATP in a Ca2+-dependent manner. The crystal structure of synC in complex with ATPgammaS and Ca2+ explains the preference of synC for Ca2+ over Mg2+. Our results suggest that synapsins may also be ATP-utilizing enzymes.
About this Structure
1AUV is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
Synapsin I is structurally similar to ATP-utilizing enzymes., Esser L, Wang CR, Hosaka M, Smagula CS, Sudhof TC, Deisenhofer J, EMBO J. 1998 Feb 16;17(4):977-84. PMID:9463376 Page seeded by OCA on Fri May 2 10:43:15 2008
