5c0c

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'''Unreleased structure'''
 
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The entry 5c0c is ON HOLD until Paper Publication
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==1E6 TCR in complex with HLA-A02 carrying RQFGPDWIVA==
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<StructureSection load='5c0c' size='340' side='right' caption='[[5c0c]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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Authors: Rizkallah, P.J., Bulek, A.M., Cole, D.K., Sewell, A.K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5c0c]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C0C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C0C FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5c06|5c06]], [[5c07|5c07]], [[5c08|5c08]], [[5c09|5c09]], [[5c0a|5c0a]], [[5c0b|5c0b]], [[5c0d|5c0d]], [[5c0e|5c0e]], [[5c0f|5c0f]], [[5c0g|5c0g]], [[5c0i|5c0i]], [[5c0j|5c0j]], [[3utp|3utp]], [[3utq|3utq]], [[3uts|3uts]], [[3utt|3utt]], [[5hyj|5hyj]], [[5c0h|5c0h]]</td></tr>
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[[Category: Sewell, A.K]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c0c OCA], [http://pdbe.org/5c0c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c0c RCSB], [http://www.ebi.ac.uk/pdbsum/5c0c PDBsum]</span></td></tr>
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[[Category: Rizkallah, P.J]]
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</table>
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[[Category: Bulek, A.M]]
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== Disease ==
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[[Category: Cole, D.K]]
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bulek, A M]]
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[[Category: Cole, D K]]
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[[Category: Rizkallah, P J]]
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[[Category: Sewell, A K]]
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[[Category: 1e6-tcr]]
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[[Category: Hla-a02]]
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[[Category: Immune system]]
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[[Category: Immuno]]

Revision as of 19:35, 13 May 2016

1E6 TCR in complex with HLA-A02 carrying RQFGPDWIVA

5c0c, resolution 1.97Å

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