1avq

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[[Image:1avq.gif|left|200px]]
[[Image:1avq.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1avq |SIZE=350|CAPTION= <scene name='initialview01'>1avq</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1avq", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_(lambda-induced) Exodeoxyribonuclease (lambda-induced)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.3 3.1.11.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1avq| PDB=1avq | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1avq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1avq OCA], [http://www.ebi.ac.uk/pdbsum/1avq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1avq RCSB]</span>
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}}
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'''TOROIDAL STRUCTURE OF LAMBDA EXONUCLEASE DETERMINED AT 2.4 ANGSTROMS'''
'''TOROIDAL STRUCTURE OF LAMBDA EXONUCLEASE DETERMINED AT 2.4 ANGSTROMS'''
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Toroidal structure of lambda-exonuclease., Kovall R, Matthews BW, Science. 1997 Sep 19;277(5333):1824-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9295273 9295273]
Toroidal structure of lambda-exonuclease., Kovall R, Matthews BW, Science. 1997 Sep 19;277(5333):1824-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9295273 9295273]
[[Category: Enterobacteria phage lambda]]
[[Category: Enterobacteria phage lambda]]
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[[Category: Exodeoxyribonuclease (lambda-induced)]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Kovall, R A.]]
[[Category: Kovall, R A.]]
[[Category: Matthews, B W.]]
[[Category: Matthews, B W.]]
[[Category: 5'-3' exonuclease]]
[[Category: 5'-3' exonuclease]]
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[[Category: deoxyribonuclease]]
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[[Category: Deoxyribonuclease]]
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[[Category: dna recombination and repair]]
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[[Category: Dna recombination and repair]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:45:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:48:24 2008''
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Revision as of 07:45, 2 May 2008

Image:1avq.gif

Template:STRUCTURE 1avq

TOROIDAL STRUCTURE OF LAMBDA EXONUCLEASE DETERMINED AT 2.4 ANGSTROMS


Overview

Structure determination at 2.4 angstrom resolution shows that lambda-exonuclease consists of three subunits that form a toroid. The central channel is funnel shaped, tapering from an inner diameter of about 30 angstroms at the wider end to 15 angstroms at the narrow end. This is adequate to accommodate the DNA substrate and thus provides a structural basis for the ability of the enzyme to sequentially hydrolyze thousands of nucleotides in a highly processive manner. The results also suggest the locations of the active sites and the constraints that limit cleavage to a single strand.

About this Structure

1AVQ is a Single protein structure of sequence from Enterobacteria phage lambda. Full crystallographic information is available from OCA.

Reference

Toroidal structure of lambda-exonuclease., Kovall R, Matthews BW, Science. 1997 Sep 19;277(5333):1824-7. PMID:9295273 Page seeded by OCA on Fri May 2 10:45:03 2008

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OCA

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