5cgq

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'''Unreleased structure'''
 
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The entry 5cgq is ON HOLD until Jul 09 2017
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==Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with F9 ligand in the alpha-site and the product L-Tryptophan in the beta-site.==
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<StructureSection load='5cgq' size='340' side='right' caption='[[5cgq]], [[Resolution|resolution]] 1.18&Aring;' scene=''>
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Authors: Hilario, E., Caulkins, B.G., Young, R.P., Dunn, M.F., Mueller, L.J., Fan, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5cgq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CGQ FirstGlance]. <br>
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Description: Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with F9 ligand in the alpha-site and the product L-Tryptophan in the beta-site.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCN:BICINE'>BCN</scene>, <scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=F9F:2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL+DIHYDROGEN+PHOSPHATE'>F9F</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ht3|4ht3]], [[4hn4|4hn4]], [[4hpj|4hpj]], [[4hpx|4hpx]], [[3pr2|3pr2]], [[2cli|2cli]], [[2cll|2cll]], [[4xug|4xug]], [[4y6g|4y6g]], [[4zqc|4zqc]], [[5bw6|5bw6]]</td></tr>
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[[Category: Mueller, L.J]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
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[[Category: Dunn, M.F]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cgq OCA], [http://pdbe.org/5cgq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cgq RCSB], [http://www.ebi.ac.uk/pdbsum/5cgq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cgq ProSAT]</span></td></tr>
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[[Category: Caulkins, B.G]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[http://www.uniprot.org/uniprot/TRPB_SALTY TRPB_SALTY]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
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__TOC__
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</StructureSection>
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[[Category: Tryptophan synthase]]
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[[Category: Caulkins, B G]]
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[[Category: Dunn, M F]]
[[Category: Fan, L]]
[[Category: Fan, L]]
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[[Category: Young, R.P]]
 
[[Category: Hilario, E]]
[[Category: Hilario, E]]
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[[Category: Mueller, L J]]
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[[Category: Young, R P]]
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[[Category: Allosteric enzyme]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: Carbon-oxygen lyase]]
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[[Category: F6f]]
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[[Category: Inhibitor]]
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[[Category: Lyase]]
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[[Category: Lyase-lyase inhibitor complex]]
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[[Category: Pyridoxal phosphate]]
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[[Category: Salmonella typhimurium]]
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[[Category: Transferase]]
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[[Category: Tryptophan biosynthesis]]

Revision as of 11:43, 14 July 2016

Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with F9 ligand in the alpha-site and the product L-Tryptophan in the beta-site.

5cgq, resolution 1.18Å

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