1aw8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1aw8.gif|left|200px]]
[[Image:1aw8.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1aw8 |SIZE=350|CAPTION= <scene name='initialview01'>1aw8</scene>, resolution 2.2&Aring;
+
The line below this paragraph, containing "STRUCTURE_1aw8", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=NUL:Pvl+Residues'>NUL</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_1-decarboxylase Aspartate 1-decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.11 4.1.1.11] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1aw8| PDB=1aw8 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aw8 OCA], [http://www.ebi.ac.uk/pdbsum/1aw8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aw8 RCSB]</span>
+
-
}}
+
'''PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE'''
'''PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE'''
Line 38: Line 35:
[[Category: Vondelf, F.]]
[[Category: Vondelf, F.]]
[[Category: Witty, M.]]
[[Category: Witty, M.]]
-
[[Category: decarboxylase]]
+
[[Category: Decarboxylase]]
-
[[Category: lyase]]
+
[[Category: Lyase]]
-
[[Category: pantothenate pathway]]
+
[[Category: Pantothenate pathway]]
-
[[Category: protein self-processing]]
+
[[Category: Protein self-processing]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:46:11 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:48:43 2008''
+

Revision as of 07:46, 2 May 2008

Image:1aw8.gif

Template:STRUCTURE 1aw8

PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE


Overview

The structure of L-aspartate-alpha-decarboxylase from E. coli has been determined at 2.2 A resolution. The enzyme is a tetramer with pseudofour-fold rotational symmetry. The subunits are six-stranded beta-barrels capped by small alpha-helices at each end. The active sites are located between adjacent subunits. The electron density provides evidence for catalytic pyruvoyl groups at three active sites and an ester at the fourth. The ester is an intermediate in the autocatalytic self-processing leading to formation of the pyruvoyl group. This unprecedented structure provides novel insights into the general phenomenon of protein processing.

About this Structure

1AW8 is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing., Albert A, Dhanaraj V, Genschel U, Khan G, Ramjee MK, Pulido R, Sibanda BL, von Delft F, Witty M, Blundell TL, Smith AG, Abell C, Nat Struct Biol. 1998 Apr;5(4):289-93. PMID:9546220 Page seeded by OCA on Fri May 2 10:46:11 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1aw8"
Personal tools