5cxv
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium== | |
| - | + | <StructureSection load='5cxv' size='340' side='right' caption='[[5cxv]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5cxv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CXV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0HK:(1R,2R,4S,5S,7S)-7-{[HYDROXY(DITHIOPHEN-2-YL)ACETYL]OXY}-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.0~2,4~]NONANE'>0HK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cxv OCA], [http://pdbe.org/5cxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cxv RCSB], [http://www.ebi.ac.uk/pdbsum/5cxv PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACM1_HUMAN ACM1_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Lysozyme]] | ||
[[Category: Feng, D]] | [[Category: Feng, D]] | ||
| + | [[Category: Kobilka, B K]] | ||
| + | [[Category: Kobilka, T S]] | ||
| + | [[Category: Li, X]] | ||
[[Category: Sun, B]] | [[Category: Sun, B]] | ||
| - | [[Category: | + | [[Category: Acetylcholine]] |
| - | [[Category: | + | [[Category: Allosteric regulation]] |
| + | [[Category: Carrier protein]] | ||
| + | [[Category: Cholinergic antagonist]] | ||
| + | [[Category: Gpcr]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Muscarinic m1]] | ||
| + | [[Category: Subtype selectivity]] | ||
| + | [[Category: Tiotropium receptor]] | ||
Revision as of 03:53, 10 March 2016
Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium
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