5cyl
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the CupB6 tip adhesin from Pseudomonas aeruginosa== | |
| + | <StructureSection load='5cyl' size='340' side='right' caption='[[5cyl]], [[Resolution|resolution]] 2.77Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5cyl]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CYL FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cyl OCA], [http://pdbe.org/5cyl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cyl RCSB], [http://www.ebi.ac.uk/pdbsum/5cyl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cyl ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Pseudomonas aeruginosa is a Gram-negative opportunistic bacterial pathogen that can cause chronic infection of the lungs of cystic fibrosis patients. Chaperone-usher systems in P. aeruginosa are known to translocate and assemble adhesive pili on the bacterial surface and contribute to biofilm formation within the host. Here, we report the crystal structure of the tip adhesion subunit CupB6 from the cupB1-6 gene cluster. The tip domain is connected to the pilus via the N-terminal donor strand from the main pilus subunit CupB1. Although the CupB6 adhesion domain bears structural features similar to other CU adhesins it displays an unusual polyproline helix adjacent to a prominent surface pocket, which are likely the site for receptor recognition. | ||
| - | + | Crystal structure of the CupB6 adhesive tip from the chaperone-usher family of pili from Pseudomonas aeruginosa.,Rasheed M, Garnett J, Perez-Dorado I, Muhl D, Filloux A, Matthews S Biochim Biophys Acta. 2016 Nov;1864(11):1500-5. doi:, 10.1016/j.bbapap.2016.07.010. Epub 2016 Jul 29. PMID:27481165<ref>PMID:27481165</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5cyl" style="background-color:#fffaf0;"></div> | |
| - | [[Category: Garnett, J | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Garnett, J A]] | ||
| + | [[Category: Matthews, S J]] | ||
[[Category: Perez-Dorado, I]] | [[Category: Perez-Dorado, I]] | ||
| + | [[Category: Rasheed, M]] | ||
| + | [[Category: Adhesion]] | ||
| + | [[Category: Biofilm]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Chaperone-usher]] | ||
| + | [[Category: Pilin]] | ||
Revision as of 21:22, 5 October 2016
Crystal structure of the CupB6 tip adhesin from Pseudomonas aeruginosa
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