5czm

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'''Unreleased structure'''
 
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The entry 5czm is ON HOLD until Paper Publication
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==Crystal structure of a mutated catalytic domain of Human MMP12 in complex with RXP470==
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<StructureSection load='5czm' size='340' side='right' caption='[[5czm]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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Authors: Rouanet-Mehouas, C., Roselia, L., Devel, L., Dive, V., Stura, E.A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5czm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CZM FirstGlance]. <br>
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Description: Crystal structure of a mutated catalytic domain of Human MMP12 in complex with RXP470
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=R47:N-[(2S)-3-[(S)-(4-BROMOPHENYL)(HYDROXY)PHOSPHORYL]-2-{[3-(3-CHLOROBIPHENYL-4-YL)-1,2-OXAZOL-5-YL]METHYL}PROPANOYL]-L-ALPHA-GLUTAMYL-L-ALPHA-GLUTAMINE'>R47</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5czm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5czm OCA], [http://pdbe.org/5czm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5czm RCSB], [http://www.ebi.ac.uk/pdbsum/5czm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5czm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
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__TOC__
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</StructureSection>
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[[Category: Macrophage elastase]]
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[[Category: Devel, L]]
[[Category: Dive, V]]
[[Category: Dive, V]]
[[Category: Roselia, L]]
[[Category: Roselia, L]]
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[[Category: Devel, L]]
 
[[Category: Rouanet-Mehouas, C]]
[[Category: Rouanet-Mehouas, C]]
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[[Category: Stura, E.A]]
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[[Category: Stura, E A]]
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[[Category: Human]]
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[[Category: Hydrolase]]
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[[Category: Macrophage]]
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[[Category: Matrix]]
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[[Category: Metallo elastase]]
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[[Category: Mmp12]]
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[[Category: Rxp470]]

Revision as of 16:20, 10 August 2016

Crystal structure of a mutated catalytic domain of Human MMP12 in complex with RXP470

5czm, resolution 1.30Å

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