5d3x
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the P-Rex1 PH domain with Inositol-(1,3,4,5)-Tetrakisphosphate Bound== | |
| - | + | <StructureSection load='5d3x' size='340' side='right' caption='[[5d3x]], [[Resolution|resolution]] 1.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5d3x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D3X FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4IP:INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE'>4IP</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5d27|5d27]], [[5d3v|5d3v]], [[5d3w|5d3w]], [[5d3y|5d3y]]</td></tr> |
| - | [[Category: Cash, J | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d3x OCA], [http://pdbe.org/5d3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d3x RCSB], [http://www.ebi.ac.uk/pdbsum/5d3x PDBsum]</span></td></tr> |
| - | [[Category: Tesmer, J | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PREX1_HUMAN PREX1_HUMAN]] Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cash, J N]] | ||
| + | [[Category: Tesmer, J J.G]] | ||
| + | [[Category: Beta sandwich]] | ||
| + | [[Category: Lipid binding protein]] | ||
| + | [[Category: Phosphatidylinositol-binding]] | ||
| + | [[Category: Pleckstrin homology domain]] | ||
Revision as of 16:58, 10 May 2016
Crystal Structure of the P-Rex1 PH domain with Inositol-(1,3,4,5)-Tetrakisphosphate Bound
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