5dil
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the effector domain of the NS1 protein from influenza virus B== | |
| - | + | <StructureSection load='5dil' size='340' side='right' caption='[[5dil]], [[Resolution|resolution]] 2.01Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5dil]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DIL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DIL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | |
| - | [[ | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dil OCA], [http://pdbe.org/5dil PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dil RCSB], [http://www.ebi.ac.uk/pdbsum/5dil PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dil ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/X2C382_9INFB X2C382_9INFB]] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.[PIRNR:PIRNR003938] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Guan, R]] | ||
[[Category: Hamilton, K]] | [[Category: Hamilton, K]] | ||
[[Category: Ma, L]] | [[Category: Ma, L]] | ||
| - | [[Category: | + | [[Category: Montelione, G T]] |
| + | [[Category: Effector domain]] | ||
| + | [[Category: Rna binding]] | ||
| + | [[Category: Rna-binding protein]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 16:22, 10 August 2016
Crystal structure of the effector domain of the NS1 protein from influenza virus B
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