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5dz6

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'''Unreleased structure'''
 
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The entry 5dz6 is ON HOLD until Paper Publication
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==Acyl transferase from Bacillaene PKS==
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<StructureSection load='5dz6' size='340' side='right' caption='[[5dz6]], [[Resolution|resolution]] 1.44&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5dz6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DZ6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Acyl-carrier-protein]_S-malonyltransferase [Acyl-carrier-protein] S-malonyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.39 2.3.1.39] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dz6 OCA], [http://pdbe.org/5dz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dz6 RCSB], [http://www.ebi.ac.uk/pdbsum/5dz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dz6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PKSC_BACSU PKSC_BACSU]] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the transfer of the malonyl-CoA group to the acyl-carrier-protein AcpK (Mal-AcpK).<ref>PMID:16757561</ref> <ref>PMID:17234808</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The antibiotic bacillaene is biosynthesized in Bacillus subtilis by a hybrid type 1 modular polyketide synthase/nonribosomal peptide synthetase of the trans-acyltransferase (trans-AT) class. Within this system, the essential acyl-group loading activity is provided by the action of three free-standing trans-acting acyltransferases. Here, the recombinant expression, purification and crystallization of the bacillaene synthase trans-acting acyltransferase PksC are reported. A diffraction data set has been collected from a single PksC crystal to 1.44 A resolution and the crystal was found to belong to the orthorhombic space group P2(1)2(1)2(1).
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Authors: Till, M., Race, P.R.
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Crystallization and preliminary X-ray analysis of the bacillaene synthase trans-acting acyltransferase PksC.,Cuskin F, Solovyova AS, Lewis RJ, Race PR Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt 4):464-6. doi:, 10.1107/S1744309111003484. Epub 2011 Mar 25. PMID:21505242<ref>PMID:21505242</ref>
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Description: Acyl transferase from Bacillaene PKS
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Race, P.R]]
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<div class="pdbe-citations 5dz6" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Race, P R]]
[[Category: Till, M]]
[[Category: Till, M]]
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[[Category: Acyltrasferase]]
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[[Category: Polyketide synthase]]
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[[Category: Transferase]]

Revision as of 21:24, 5 October 2016

Acyl transferase from Bacillaene PKS

5dz6, resolution 1.44Å

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