5e1a

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'''Unreleased structure'''
 
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The entry 5e1a is ON HOLD until Paper Publication
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==Structure of KcsA with L24C/R117C mutations==
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<StructureSection load='5e1a' size='340' side='right' caption='[[5e1a]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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Authors: Upadhyay, V., Kim, D.M., Nimigean, C.M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5e1a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E1A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E1A FirstGlance]. <br>
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Description: Structure of KcsA with L24C/R117C mutations
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e1a OCA], [http://pdbe.org/5e1a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e1a RCSB], [http://www.ebi.ac.uk/pdbsum/5e1a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e1a ProSAT]</span></td></tr>
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[[Category: Kim, D.M]]
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</table>
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[[Category: Nimigean, C.M]]
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== Function ==
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[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Mus musculus]]
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[[Category: Kim, D M]]
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[[Category: Nimigean, C M]]
[[Category: Upadhyay, V]]
[[Category: Upadhyay, V]]
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[[Category: Kcsa]]
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[[Category: Metal transport]]
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[[Category: Mutation]]
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[[Category: Potassium channel]]
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[[Category: Proton]]

Revision as of 11:43, 14 July 2016

Structure of KcsA with L24C/R117C mutations

5e1a, resolution 3.40Å

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