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5ejw
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS351== | |
| - | + | <StructureSection load='5ejw' size='340' side='right' caption='[[5ejw]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ejw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EJW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5PZ:(1~{R})-2-[2-AZANYLIDENE-3-[(2-METHYLPHENYL)METHYL]BENZIMIDAZOL-1-YL]-1-(3,4-DICHLOROPHENYL)ETHANOL'>5PZ</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ejw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ejw OCA], [http://pdbe.org/5ejw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ejw RCSB], [http://www.ebi.ac.uk/pdbsum/5ejw PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CBX7_MOUSE CBX7_MOUSE]] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded RNA. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.<ref>PMID:16537902</ref> <ref>PMID:20541999</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Ren, C]] | [[Category: Ren, C]] | ||
| - | [[Category: Zhou, M | + | [[Category: Zhou, M M]] |
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription-inhibitor complex]] | ||
Revision as of 03:56, 10 March 2016
Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS351
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