1azs

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[[Image:1azs.jpg|left|200px]]
[[Image:1azs.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1azs |SIZE=350|CAPTION= <scene name='initialview01'>1azs</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1azs", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=MGB:Mg+Binding+Site+In+Active+Site+Of+Adenylyl+Cyclase'>MGB</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FKP:METHYLPIPERAZINOFORSKOLIN'>FKP</scene>, <scene name='pdbligand=GSP:5&#39;-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ADENYLYL CYCLASE TYPE V ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 Canis lupus familiaris]), ADENYLYL CYCLASE TYPE II ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), GNAS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])
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-->
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|DOMAIN=
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{{STRUCTURE_1azs| PDB=1azs | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1azs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1azs OCA], [http://www.ebi.ac.uk/pdbsum/1azs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1azs RCSB]</span>
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}}
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'''COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE'''
'''COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE'''
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[[Category: Sprang, S R.]]
[[Category: Sprang, S R.]]
[[Category: Tesmer, J J.G.]]
[[Category: Tesmer, J J.G.]]
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[[Category: complex (lyase/hydrolase)]]
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[[Category: Cyclase]]
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[[Category: cyclase]]
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[[Category: Effector enzyme]]
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[[Category: effector enzyme]]
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[[Category: Hydrolase]]
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[[Category: hydrolase]]
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[[Category: Signal transducing protein]]
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[[Category: signal transducing protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:53:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:50:51 2008''
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Revision as of 07:53, 2 May 2008

Image:1azs.jpg

Template:STRUCTURE 1azs

COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE


Overview

The crystal structure of a soluble, catalytically active form of adenylyl cyclase in a complex with its stimulatory heterotrimeric G protein alpha subunit (Gsalpha) and forskolin was determined to a resolution of 2.3 angstroms. When P-site inhibitors were soaked into native crystals of the complex, the active site of adenylyl cyclase was located and structural elements important for substrate recognition and catalysis were identified. On the basis of these and other structures, a molecular mechanism is proposed for the activation of adenylyl cyclase by Gsalpha.

About this Structure

1AZS is a Protein complex structure of sequences from Bos taurus, Canis lupus familiaris and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS., Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR, Science. 1997 Dec 12;278(5345):1907-16. PMID:9417641 Page seeded by OCA on Fri May 2 10:53:22 2008

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OCA

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