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Cyclophilin
From Proteopedia
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<StructureSection load='2x25' size='350' side='right' caption='Human Cyclophilin-A with acetyllysine (PDB entry [[2x25]])' scene=''> | <StructureSection load='2x25' size='350' side='right' caption='Human Cyclophilin-A with acetyllysine (PDB entry [[2x25]])' scene=''> | ||
| + | == Function == | ||
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| + | [[Cyclophilin]] (Cyp) binds cyclosporin. They are peptidylprolyl isomerases which catalyze the isomerisation of proline. The '''Cyp-A/cyclosporin A''' complex inhibits organ rejection. '''Cyp-D''' is a component of the mitochondria permeability pore. Rotamase such as FKBP is a prokaryotic Cyp which is not inhibited by cyclosporin but by FK-506 – an immunosuppressive drug. <ref>PMID:14731520</ref> | ||
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| + | == Relevance == | ||
| - | + | Cyc | |
</StructureSection> | </StructureSection> | ||
== 3D Structures of Cyclophilin == | == 3D Structures of Cyclophilin == | ||
Revision as of 08:21, 17 December 2015
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3D Structures of Cyclophilin
Updated on 17-December-2015
