Cocaine esterase

(Difference between revisions)

Revision as of 06:17, 18 February 2019

Cocaine esterase complex with reaction product benzoic acid (PDB entry 1l7q)

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Updated on 18-February-2019

↑ Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA. Crystal structure of a bacterial cocaine esterase. Nat Struct Biol. 2002 Jan;9(1):17-21. PMID:11742345 doi:10.1038/nsb742

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 == Structural highlights ==
-CocE contains 3 domains.  <scene name='48/489298/Cv/2'>Domain 1</scene> contains the catalytic triad: Ser, Asp and His typical of the hydrolase family.  <scene name='48/489298/Cv/3'>Domains 2 and 3</scene> are involved in substrate recognition.  <scene name='48/489298/Cv/4'>The active site</scene> is located at a cleft in the interface of the 3 domains and contains the <scene name='48/489298/Cv/6'>catalytic triad Ser-Asp-His</scene>.
+CocE contains 3 domains.  <scene name='48/489298/Cv/5'>Domain 1</scene> contains the catalytic triad: Ser, Asp and His typical of the hydrolase family.  <scene name='48/489298/Cv/3'>Domains 2 and 3</scene> are involved in substrate recognition.  <scene name='48/489298/Cv/4'>The active site</scene> is located at a cleft in the interface of the 3 domains and contains the <scene name='48/489298/Cv/6'>catalytic triad Ser-Asp-His</scene>.
 </StructureSection>
 ==3D structures of cocaine esterase==