1b3j

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[[Image:1b3j.gif|left|200px]]
[[Image:1b3j.gif|left|200px]]
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{{Structure
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|PDB= 1b3j |SIZE=350|CAPTION= <scene name='initialview01'>1b3j</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1b3j", creates the "Structure Box" on the page.
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|GENE= MICA-001 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1b3j| PDB=1b3j | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b3j OCA], [http://www.ebi.ac.uk/pdbsum/1b3j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1b3j RCSB]</span>
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'''STRUCTURE OF THE MHC CLASS I HOMOLOG MIC-A, A GAMMADELTA T CELL LIGAND'''
'''STRUCTURE OF THE MHC CLASS I HOMOLOG MIC-A, A GAMMADELTA T CELL LIGAND'''
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[[Category: Strong, R.]]
[[Category: Strong, R.]]
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[[Category: Gamma-delta-tcr]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: hc i homolog]]
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[[Category: Hc i homolog]]
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[[Category: human mica]]
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[[Category: Human mica]]
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[[Category: immunology]]
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[[Category: Immunology]]
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[[Category: mhc]]
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[[Category: Mhc]]
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[[Category: mica]]
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[[Category: Mica]]
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[[Category: signa immunoglobulin fold]]
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[[Category: Signa immunoglobulin fold]]
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[[Category: t-cell]]
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[[Category: T-cell]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:01:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:52:48 2008''
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Revision as of 08:01, 2 May 2008

Image:1b3j.gif

Template:STRUCTURE 1b3j

STRUCTURE OF THE MHC CLASS I HOMOLOG MIC-A, A GAMMADELTA T CELL LIGAND


Overview

The major histocompatibility complex (MHC) class I homolog MIC-A functions as a stress-inducible antigen that is recognized by a subset of gammadelta T cells independent of beta2-microglobulin and bound peptides. Its crystal structure reveals a dramatically altered MHC class I fold, both in detail and overall domain organization. The only remnant of a peptide-binding groove is a small cavity formed as the result of disordering a large section of one of the groove-defining helices. Loss of beta2-microglobulin binding is due to a restructuring of the interaction interfaces. Structural mapping of sequence variation suggests potential receptor binding sites on the underside of the platform on the side opposite of the surface recognized by alphabeta T cell receptors on MHC class I-peptide complexes.

About this Structure

1B3J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand., Li P, Willie ST, Bauer S, Morris DL, Spies T, Strong RK, Immunity. 1999 May;10(5):577-84. PMID:10367903 Page seeded by OCA on Fri May 2 11:01:09 2008

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