Deaminase
From Proteopedia
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'''Deaminase''' removes an amine group from an amino acid and the rest of the molecule is recycled. <br /> | '''Deaminase''' removes an amine group from an amino acid and the rest of the molecule is recycled. <br /> | ||
* '''Cytosine deaminase''' (CDA) converts cytosine to uracil. <br /> | * '''Cytosine deaminase''' (CDA) converts cytosine to uracil. <br /> | ||
| - | * '''Cytidine deaminase''' (CDDA) converts cytidine to uridine. <ref>PMID: | + | * '''Cytidine deaminase''' (CDDA) converts cytidine to uridine. <ref>PMID:12651944</ref> <br /> |
* '''5-methylcytosine deaminase''' (MCDA) produces thymine. <br /> | * '''5-methylcytosine deaminase''' (MCDA) produces thymine. <br /> | ||
* '''Guanine deaminase''' (GDA) converts guanine to xanthine. <ref>PMID:22662200</ref><br /> | * '''Guanine deaminase''' (GDA) converts guanine to xanthine. <ref>PMID:22662200</ref><br /> | ||
Revision as of 12:31, 21 December 2015
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3D Structures of deaminase
Updated on 21-December-2015
References
- ↑ Bransteitter R, Pham P, Scharff MD, Goodman MF. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4102-7. Epub 2003 Mar 21. PMID:12651944 doi:http://dx.doi.org/10.1073/pnas.0730835100
- ↑ Egeblad L, Welin M, Flodin S, Graslund S, Wang L, Balzarini J, Eriksson S, Nordlund P. Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism. PLoS One. 2012;7(5):e37724. Epub 2012 May 25. PMID:22662200 doi:10.1371/journal.pone.0037724
- ↑ Negroni L, Samson M, Guigonis JM, Rossi B, Pierrefite-Carle V, Baudoin C. Treatment of colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation. Mol Cancer Ther. 2007 Oct;6(10):2747-56. PMID:17938268 doi:http://dx.doi.org/10.1158/1535-7163.MCT-07-0040
