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Deaminase

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<StructureSection load='1aln' size='350' side='right' caption='Structure of cytidine deaminase complex with deazacytosine (PDB entry [[1aln]])' scene=''>
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<StructureSection load='1p6o' size='350' side='right' caption='Structure of cytidine deaminase complex with deazacytosine (PDB entry [[1aln]])' scene=''>
== Function ==
== Function ==
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Cytosine deaminase is used in cancer therapy. After treatment by 5-fluorouracil, the cytosine deaminase gene is introduced to the tumor resulting in intratumor chemotherapy. <ref>PMID:17938268</ref>
Cytosine deaminase is used in cancer therapy. After treatment by 5-fluorouracil, the cytosine deaminase gene is introduced to the tumor resulting in intratumor chemotherapy. <ref>PMID:17938268</ref>
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== Disease ==
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Mutation in adenine deaminase results in deficiency of the enzyme and is the cause of severe combined immunodeficiency (SCID).
</StructureSection>
</StructureSection>

Revision as of 07:34, 22 December 2015

Structure of cytidine deaminase complex with deazacytosine (PDB entry 1aln)

Drag the structure with the mouse to rotate

3D Structures of deaminase

Updated on 22-December-2015

References

  1. ↑ Bransteitter R, Pham P, Scharff MD, Goodman MF. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4102-7. Epub 2003 Mar 21. PMID:12651944 doi:http://dx.doi.org/10.1073/pnas.0730835100
  2. ↑ Egeblad L, Welin M, Flodin S, Graslund S, Wang L, Balzarini J, Eriksson S, Nordlund P. Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism. PLoS One. 2012;7(5):e37724. Epub 2012 May 25. PMID:22662200 doi:10.1371/journal.pone.0037724
  3. ↑ Negroni L, Samson M, Guigonis JM, Rossi B, Pierrefite-Carle V, Baudoin C. Treatment of colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation. Mol Cancer Ther. 2007 Oct;6(10):2747-56. PMID:17938268 doi:http://dx.doi.org/10.1158/1535-7163.MCT-07-0040

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Michal Harel, Alexander Berchansky

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