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Deaminase

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<StructureSection load='1p6o' size='350' side='right' caption='Structure of cytidine deaminase complex with deazacytosine (PDB entry [[1aln]])' scene=''>
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<StructureSection load='1p6o' size='350' side='right' caption='Structure of yeast cytosine deaminase complex with pyridine-based inhibitor, acetate, Ca+2 (green) and Zn+2 (grey) ions (PDB entry [[1p6o]])' scene=''>
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== Function ==
== Function ==
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Mutation in adenine deaminase results in deficiency of the enzyme and is the cause of severe combined immunodeficiency (SCID).
Mutation in adenine deaminase results in deficiency of the enzyme and is the cause of severe combined immunodeficiency (SCID).
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== Structural highlights ==
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The active site of cytosine deaminase contains a catalytically active zinc atom.<ref>PMID:12906827</ref>
</StructureSection>
</StructureSection>

Revision as of 07:46, 22 December 2015

Structure of yeast cytosine deaminase complex with pyridine-based inhibitor, acetate, Ca+2 (green) and Zn+2 (grey) ions (PDB entry 1p6o)

Drag the structure with the mouse to rotate

3D Structures of deaminase

Updated on 22-December-2015

References

  1. ↑ Bransteitter R, Pham P, Scharff MD, Goodman MF. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4102-7. Epub 2003 Mar 21. PMID:12651944 doi:http://dx.doi.org/10.1073/pnas.0730835100
  2. ↑ Egeblad L, Welin M, Flodin S, Graslund S, Wang L, Balzarini J, Eriksson S, Nordlund P. Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism. PLoS One. 2012;7(5):e37724. Epub 2012 May 25. PMID:22662200 doi:10.1371/journal.pone.0037724
  3. ↑ Negroni L, Samson M, Guigonis JM, Rossi B, Pierrefite-Carle V, Baudoin C. Treatment of colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation. Mol Cancer Ther. 2007 Oct;6(10):2747-56. PMID:17938268 doi:http://dx.doi.org/10.1158/1535-7163.MCT-07-0040
  4. ↑ Ireton GC, Black ME, Stoddard BL. The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy. Structure. 2003 Aug;11(8):961-72. PMID:12906827

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Michal Harel, Alexander Berchansky

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