Deoxyuridine 5'-triphosphate nucleotidohydrolase
From Proteopedia
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<StructureSection load='1smc' size='350' side='right' caption='dUTPase trimer complex with dUTP (stick model), nitrate and Tris (PDB entry [[1smc]])' scene=''> | <StructureSection load='1smc' size='350' side='right' caption='dUTPase trimer complex with dUTP (stick model), nitrate and Tris (PDB entry [[1smc]])' scene=''> | ||
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'''Deoxyuridine 5’-triphosphate nucleotidohydrolase''' (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi). DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway. | '''Deoxyuridine 5’-triphosphate nucleotidohydrolase''' (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi). DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway. | ||
| - | Prokaryotic DUTP contains metal ion. <ref>PMID: | + | Prokaryotic DUTP contains metal ion. <ref>PMID:18837522</ref> |
== Relevance == | == Relevance == | ||
Revision as of 09:14, 23 December 2015
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3D structures of dUTPase
Updated on 23-December-2015
References
- ↑ Vertessy BG, Toth J. Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases. Acc Chem Res. 2009 Jan 20;42(1):97-106. PMID:18837522 doi:10.1021/ar800114w
