5ev5
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of murine neuroglobin mutant V101F at 150 MPa pressure== | |
| - | + | <StructureSection load='5ev5' size='340' side='right' caption='[[5ev5]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ev5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EV5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eet|5eet]], [[5eu2|5eu2]]</td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ev5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ev5 OCA], [http://pdbe.org/5ev5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ev5 RCSB], [http://www.ebi.ac.uk/pdbsum/5ev5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ev5 ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NGB_MOUSE NGB_MOUSE]] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11473111</ref> <ref>PMID:11473128</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Girard, E]] | [[Category: Girard, E]] | ||
[[Category: Prange, T]] | [[Category: Prange, T]] | ||
| + | [[Category: Vallone, B]] | ||
| + | [[Category: H, N Colloc]] | ||
| + | [[Category: Globin]] | ||
| + | [[Category: Oxygen storage-transporter]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 00:56, 20 October 2016
Crystal structure of murine neuroglobin mutant V101F at 150 MPa pressure
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