5fai

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m (Protected "5fai" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==EMG1 N1-Specific Pseudouridine Methyltransferase==
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<StructureSection load='5fai' size='340' side='right' caption='[[5fai]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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The entry 5fai is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5fai]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FAI FirstGlance]. <br>
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Authors: DONG, A., ZENG, H., LI, Y., TEMPEL, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fai OCA], [http://pdbe.org/5fai PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fai RCSB], [http://www.ebi.ac.uk/pdbsum/5fai PDBsum]</span></td></tr>
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Description: EMG1 N1-Specific Pseudouridine Methyltransferase
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</table>
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[[Category: Unreleased Structures]]
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== Disease ==
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[[Category: Dong, A]]
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[[http://www.uniprot.org/uniprot/NEP1_HUMAN NEP1_HUMAN]] Bowen-Conradi syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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[[Category: Li, Y]]
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== Function ==
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[[Category: Zeng, H]]
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[[http://www.uniprot.org/uniprot/NEP1_HUMAN NEP1_HUMAN]] S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity).[UniProtKB:Q06287]<ref>PMID:20047967</ref>
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[[Category: Wu, H]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: BROWN, P J]]
[[Category: Bountra, C]]
[[Category: Bountra, C]]
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[[Category: Tempel, W]]
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[[Category: DONG, A]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Edwards, A M]]
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[[Category: Brown, P.J]]
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[[Category: LI, Y]]
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[[Category: Edwards, A.M]]
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[[Category: Structural genomic]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: TEMPEL, W]]
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[[Category: WU, H]]
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[[Category: ZENG, H]]
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[[Category: Emg1]]
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[[Category: Methyltransferase]]
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[[Category: Sgc]]
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[[Category: Transferase]]

Revision as of 17:26, 20 January 2016

EMG1 N1-Specific Pseudouridine Methyltransferase

5fai, resolution 1.80Å

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