5fbx
From Proteopedia
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| - | ''' | + | ==Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor== |
| - | + | <StructureSection load='5fbx' size='340' side='right' caption='[[5fbx]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fbx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FBX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5W4:(3~{S})-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-2-METHYL-3-PHENYL-3~{H}-ISOINDOL-1-ONE'>5W4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbx OCA], [http://pdbe.org/5fbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fbx RCSB], [http://www.ebi.ac.uk/pdbsum/5fbx PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Brennan, P E]] | ||
| + | [[Category: Clark, P G.K]] | ||
| + | [[Category: Delft, F von]] | ||
| + | [[Category: Dixon, D]] | ||
| + | [[Category: Edwards, A M]] | ||
[[Category: Fedorov, O]] | [[Category: Fedorov, O]] | ||
| + | [[Category: Knapp, S]] | ||
[[Category: Muller, S]] | [[Category: Muller, S]] | ||
| + | [[Category: Nowak, R]] | ||
[[Category: Siejka, P]] | [[Category: Siejka, P]] | ||
| - | [[Category: Knapp, S]] | ||
| - | [[Category: Clark, P.G.K]] | ||
| - | [[Category: Bountra, C]] | ||
| - | [[Category: Arrowsmith, C.H]] | ||
| - | [[Category: Dixon, D]] | ||
| - | [[Category: Von Delft, F]] | ||
| - | [[Category: Edwards, A.M]] | ||
| - | [[Category: Tallant, C]] | ||
[[Category: Srikannathasan, V]] | [[Category: Srikannathasan, V]] | ||
| + | [[Category: Tallant, C]] | ||
| + | [[Category: Baf180]] | ||
| + | [[Category: Brg1-associated factor 180]] | ||
| + | [[Category: Chromatin remodeling]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 19:41, 30 December 2015
Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor
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