5fc8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Mouse importin alpha: Dengue 3 NS5 C-terminal NLS peptide complex== | |
| - | + | <StructureSection load='5fc8' size='340' side='right' caption='[[5fc8]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fc8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FC8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fc8 OCA], [http://pdbe.org/5fc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fc8 RCSB], [http://www.ebi.ac.uk/pdbsum/5fc8 PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[Category: Forwood, J | + | == Function == |
| - | [[Category: Smith, K | + | [[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Forwood, J K]] | ||
| + | [[Category: Smith, K M]] | ||
| + | [[Category: Dengue]] | ||
| + | [[Category: Importin]] | ||
| + | [[Category: Ns5]] | ||
| + | [[Category: Protein transport-viral protein complex]] | ||
Revision as of 15:52, 1 June 2016
Mouse importin alpha: Dengue 3 NS5 C-terminal NLS peptide complex
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