1b73

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[[Image:1b73.jpg|left|200px]]
[[Image:1b73.jpg|left|200px]]
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{{Structure
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|PDB= 1b73 |SIZE=350|CAPTION= <scene name='initialview01'>1b73</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1b73", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_racemase Glutamate racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.3 5.1.1.3] </span>
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{{STRUCTURE_1b73| PDB=1b73 | SCENE= }}
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|RELATEDENTRY=[[1b74|1B74]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b73 OCA], [http://www.ebi.ac.uk/pdbsum/1b73 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1b73 RCSB]</span>
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'''GLUTAMATE RACEMASE FROM AQUIFEX PYROPHILUS'''
'''GLUTAMATE RACEMASE FROM AQUIFEX PYROPHILUS'''
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[[Category: Kim, S S.]]
[[Category: Kim, S S.]]
[[Category: Yu, Y G.]]
[[Category: Yu, Y G.]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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[[Category: racemase]]
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[[Category: Racemase]]
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Revision as of 08:09, 2 May 2008

Image:1b73.jpg

Template:STRUCTURE 1b73

GLUTAMATE RACEMASE FROM AQUIFEX PYROPHILUS


Overview

Glutamate racemase (MurI) is responsible for the synthesis of D-glutamate, an essential building block of the peptidoglycan layer in bacterial cell walls. The crystal structure of glutamate racemase from Aquifex pyrophilus, determined at 2.3 A resolution, reveals that the enzyme forms a dimer and each monomer consists of two alpha/beta fold domains, a unique structure that has not been observed in other racemases or members of an enolase superfamily. A substrate analog, D-glutamine, binds to the deep pocket formed by conserved residues from two monomers. The structural and mutational analyses allow us to propose a mechanism of metal cofactor-independent glutamate racemase in which two cysteine residues are involved in catalysis.

About this Structure

1B73 is a Single protein structure of sequence from Aquifex pyrophilus. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of glutamate racemase from Aquifex pyrophilus., Hwang KY, Cho CS, Kim SS, Sung HC, Yu YG, Cho Y, Nat Struct Biol. 1999 May;6(5):422-6. PMID:10331867 Page seeded by OCA on Fri May 2 11:09:13 2008

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