1b86

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[[Image:1b86.gif|left|200px]]
[[Image:1b86.gif|left|200px]]
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{{Structure
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|PDB= 1b86 |SIZE=350|CAPTION= <scene name='initialview01'>1b86</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1b86", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DDH:[7,12-DEACETYL-3,8,13,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPANOATO(2-)-N21,N22,N23,N24]-IRON'>DDH</scene>, <scene name='pdbligand=DG2:2,3-DIPHOSPHOGLYCERIC+ACID'>DG2</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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{{STRUCTURE_1b86| PDB=1b86 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b86 OCA], [http://www.ebi.ac.uk/pdbsum/1b86 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1b86 RCSB]</span>
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'''HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX'''
'''HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX'''
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[[Category: Mauguen, Y.]]
[[Category: Mauguen, Y.]]
[[Category: Richard, V.]]
[[Category: Richard, V.]]
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[[Category: 2]]
 
[[Category: 3-diphosphoglycerate]]
[[Category: 3-diphosphoglycerate]]
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[[Category: allosteric effector]]
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[[Category: Allosteric effector]]
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[[Category: haemoglobin]]
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[[Category: Haemoglobin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:11:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:55:34 2008''
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Revision as of 08:11, 2 May 2008

Image:1b86.gif

Template:STRUCTURE 1b86

HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX


Overview

The haemoglobin-2,3-diphosphoglycerate complex structure has been solved at 2.5 A resolution using crystals grown from low-salt solutions. The results show some important differences with the precedent haemoglobin-2,3-diphosphoglycerate high-salt structure solved by Arnone. First, we observe a loss of symmetry in the binding site, secondly both of the lysine residues 82 beta interact with 2,3-diphosphoglycerate at the same time, each making two contacts. This level of interaction is in agreement with the functional behaviour of natural haemoglobin mutants with mutations at the 2,3-diphosphoglycerate binding site.

About this Structure

1B86 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Human deoxyhaemoglobin-2,3-diphosphoglycerate complex low-salt structure at 2.5 A resolution., Richard V, Dodson GG, Mauguen Y, J Mol Biol. 1993 Sep 20;233(2):270-4. PMID:8377203 Page seeded by OCA on Fri May 2 11:11:28 2008

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