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Cytochrome P450

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<StructureSection load='1og5' size='450' side='right' caption='Cytochrome P450 CypC2 with heme C complex with warfarin (PDB entry [[1og5]])' scene='43/430105/Cv/2'>
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<StructureSection load='1og5' size='350' side='right' caption='Cytochrome P450 CypC2 with heme C complex with warfarin (PDB entry [[1og5]])' scene='43/430105/Cv/2'>
[[Cytochrome P450]] (P450) catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene.<ref>PMID:12369887</ref> For details on the human P45019 family see [[Aromatase]].<br />
[[Cytochrome P450]] (P450) catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene.<ref>PMID:12369887</ref> For details on the human P45019 family see [[Aromatase]].<br />
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**[[2jjn]], [[2jjo]] - SeP450113A1 (mutant)<br />
**[[2jjn]], [[2jjo]] - SeP450113A1 (mutant)<br />
**[[2jjp]] - SeP450113A1 (mutant)+ketoconazole<br />
**[[2jjp]] - SeP450113A1 (mutant)+ketoconazole<br />
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**[[2vrv]] - SeP450113A1 (mutant)+clotrimazole<br />
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**[[2xfh]] - SeP450113A1 (mutant)+clotrimazole<br />
**[[3a1l]] – SsP450245A1+dichlorochrompyrrolic acid – ''Streptomyces sp.''<br />
**[[3a1l]] – SsP450245A1+dichlorochrompyrrolic acid – ''Streptomyces sp.''<br />
**[[2z3t]] - SsP450245A1<br />
**[[2z3t]] - SsP450245A1<br />

Revision as of 09:51, 16 November 2016

Cytochrome P450 CypC2 with heme C complex with warfarin (PDB entry 1og5)

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3D Structures of Cytochrome P450

Updated on 16-November-2016

References

  1. ↑ Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561-97. PMID:12369887
  2. ↑ Williams PA, Cosme J, Ward A, Angove HC, Matak Vinkovic D, Jhoti H. Crystal structure of human cytochrome P450 2C9 with bound warfarin. Nature. 2003 Jul 24;424(6947):464-8. Epub 2003 Jul 13. PMID:12861225 doi:http://dx.doi.org/10.1038/nature01862

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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