Diguanylate cyclase

From Proteopedia

Revision as of 14:26, 29 December 2015

spinqualitylabelsall models Diguanylate cyclase GGDEF domain complex with cyclic di-GMP, Mg+2 ion (green) and PEG (PDB code 3qyy). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Diguanylate cyclase (DGC) catalyzes the conversion of GTP to cyclic di-GMP and diphosphate. [1] For more details see PleD catalysis. Relevance DGC from Borrelia burgdorferi is involved in the transmission of spirochetes from ticks to mammals causing Lyme Disease. Structural highlights DGC contains the sequence in its active site. Cyclic di-GMP and Mg+2 ion interact with two monomers of DGC.[2]

3D Structures of diguanylate cyclase

Updated on 29-December-2015

References

1. ↑ Stock AM. Diguanylate cyclase activation: it takes two. Structure. 2007 Aug;15(8):887-8. PMID:17697992 doi:http://dx.doi.org/10.1016/j.str.2007.07.003
2. ↑ Yang CY, Chin KH, Chuah ML, Liang ZX, Wang AH, Chou SH. The structure and inhibition of a GGDEF diguanylate cyclase complexed with (c-di-GMP)(2) at the active site. Acta Crystallogr D Biol Crystallogr. 2011 Dec;67(Pt 12):997-1008. Epub 2011 Nov, 18. PMID:22120736 doi:10.1107/S090744491104039X