2na6
From Proteopedia
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| - | ''' | + | ==Transmembrane domain of mouse Fas/CD95 death receptor== |
| - | + | <StructureSection load='2na6' size='340' side='right' caption='[[2na6]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2na6]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NA6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NA6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2na7|2na7]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2na6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2na6 OCA], [http://pdbe.org/2na6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2na6 RCSB], [http://www.ebi.ac.uk/pdbsum/2na6 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/TNR6_MOUSE TNR6_MOUSE]] Note=Defects in Fas are the cause of the lymphoproliferation phenotype (lpr). Lpr mice show lymphadenopathy and autoantibody production. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TNR6_MOUSE TNR6_MOUSE]] Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chou, J J]] | ||
[[Category: Fu, Q]] | [[Category: Fu, Q]] | ||
[[Category: Fu, T]] | [[Category: Fu, T]] | ||
| - | [[Category: Membrane Protein Structures | + | [[Category: MPSbyNMR, Membrane Protein Structures by Solution NMR]] |
| - | + | ||
[[Category: Wu, H]] | [[Category: Wu, H]] | ||
| + | [[Category: Apoptosis]] | ||
| + | [[Category: Proline-based motif]] | ||
| + | [[Category: Transmembrane domain]] | ||
| + | [[Category: Transmembrane helix trimer]] | ||
Revision as of 02:24, 28 January 2016
Transmembrane domain of mouse Fas/CD95 death receptor
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