1bax
From Proteopedia
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'''MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NMR, AVERAGE STRUCTURE''' | '''MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NMR, AVERAGE STRUCTURE''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BAX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_mason-pfizer_virus Simian mason-pfizer virus]. This structure supersedes the now removed PDB entry | + | 1BAX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_mason-pfizer_virus Simian mason-pfizer virus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1at7 1at7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAX OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Matthews, S.]] | [[Category: Matthews, S.]] | ||
[[Category: Ruml, T.]] | [[Category: Ruml, T.]] | ||
| - | [[Category: | + | [[Category: Core protein]] |
| - | [[Category: | + | [[Category: Matrix protein]] |
| - | [[Category: | + | [[Category: Myristylation]] |
| - | [[Category: | + | [[Category: Polyprotein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:17:26 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:17, 2 May 2008
MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NMR, AVERAGE STRUCTURE
Overview
The Mason-Pfizer monkey virus (M-PMV) is the prototype of the type D retroviruses. In type B and D retroviruses, the Gag protein pre-assembles before association with the membrane, whereas in type C retroviruses (lentiviruses, BLV/HTLV group) Gag is targeted efficiently to the plasma membrane, where the particle formation occurs. The N-terminal domain of Gag, the matrix protein (MA), plays a critical role in determining this morphogenic difference. We have determined the three-dimensional solution structure of the M-PMV MA by heteronuclear nuclear magnetic resonance. The protein contains four alpha-helices that are structurally similar to the known type C MA structures. This similarity implies possible common assembly units and membrane-binding mechanisms for type C and B/D retroviruses. In addition to this, the interpretation of mutagenesis data has enabled us to identify, for the first time, the structural basis of a putative intracellular targeting motif.
About this Structure
1BAX is a Single protein structure of sequence from Simian mason-pfizer virus. This structure supersedes the now removed PDB entry 1at7. Full crystallographic information is available from OCA.
Reference
The three-dimensional solution structure of the matrix protein from the type D retrovirus, the Mason-Pfizer monkey virus, and implications for the morphology of retroviral assembly., Conte MR, Klikova M, Hunter E, Ruml T, Matthews S, EMBO J. 1997 Oct 1;16(19):5819-26. PMID:9312040 Page seeded by OCA on Fri May 2 11:17:26 2008
