5fgy
From Proteopedia
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| - | ''' | + | ==Structure of human adenovirus 2 protease with cofactor pVIC== |
| - | + | <StructureSection load='5fgy' size='340' side='right' caption='[[5fgy]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fgy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FGY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1avp|1avp]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenain Adenain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.39 3.4.22.39] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fgy OCA], [http://pdbe.org/5fgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fgy RCSB], [http://www.ebi.ac.uk/pdbsum/5fgy PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Davis, R | + | [[http://www.uniprot.org/uniprot/PRO_ADE02 PRO_ADE02]] Cleaves viral precursor proteins (pTP, pIIIa, pVI, pVII, pVIII, and pX) inside newly assembled particles giving rise to mature virions. Protease complexed to its cofactor slides along the viral DNA to specifically locate and cleave the viral precursors. Mature virions have a weakened organization compared to the unmature virions, thereby facilitating subsequent uncoating. Without maturation, the particle lacks infectivity and is unable to uncoat. Late in adenovirus infection, in the cytoplasm, may participate in the cytoskeleton destruction. Cleaves host cells cytoskeletal keratins K7 and K18.<ref>PMID:22791715</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Adenain]] | ||
| + | [[Category: Davis, R R]] | ||
[[Category: Hollis, T]] | [[Category: Hollis, T]] | ||
| + | [[Category: Martinez, P]] | ||
| + | [[Category: Cofactor]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Protease]] | ||
Revision as of 20:37, 13 January 2016
Structure of human adenovirus 2 protease with cofactor pVIC
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Categories: Adenain | Davis, R R | Hollis, T | Martinez, P | Cofactor | Complex | Hydrolase | Protease
