1bbs

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[[Image:1bbs.gif|left|200px]]
[[Image:1bbs.gif|left|200px]]
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{{Structure
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|PDB= 1bbs |SIZE=350|CAPTION= <scene name='initialview01'>1bbs</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1bbs", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] </span>
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{{STRUCTURE_1bbs| PDB=1bbs | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bbs OCA], [http://www.ebi.ac.uk/pdbsum/1bbs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bbs RCSB]</span>
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}}
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'''X-RAY ANALYSES OF PEPTIDE INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS'''
'''X-RAY ANALYSES OF PEPTIDE INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS'''
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[[Category: Blundell, T L.]]
[[Category: Blundell, T L.]]
[[Category: Dhanaraj, V.]]
[[Category: Dhanaraj, V.]]
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[[Category: aspartic proteinase]]
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[[Category: Aspartic proteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:18:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:57:41 2008''
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Revision as of 08:18, 2 May 2008

Image:1bbs.gif

Template:STRUCTURE 1bbs

X-RAY ANALYSES OF PEPTIDE INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS


Overview

X-ray analyses have defined the three-dimensional structures of crystals of mouse and human renins complexed with peptide inhibitors at resolutions of 1.9 and 2.8 A, respectively. The exquisite specificity of renin arises partly from ordered loop regions at the periphery of the binding cleft. Although the pattern of main-chain hydrogen bonding in other aspartic proteinase inhibitor complexes is conserved in renins, differences in the positions of secondary structure elements (particularly helices) also lead to improved specificity in renins for angiotensinogen substrates.

About this Structure

1BBS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins., Dhanaraj V, Dealwis CG, Frazao C, Badasso M, Sibanda BL, Tickle IJ, Cooper JB, Driessen HP, Newman M, Aguilar C, et al., Nature. 1992 Jun 11;357(6378):466-72. PMID:1608447 Page seeded by OCA on Fri May 2 11:18:49 2008

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