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1bc7
From Proteopedia
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[[Image:1bc7.gif|left|200px]] | [[Image:1bc7.gif|left|200px]] | ||
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'''SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX''' | '''SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX''' | ||
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[[Category: Mo, Y.]] | [[Category: Mo, Y.]] | ||
[[Category: Vaessen, B.]] | [[Category: Vaessen, B.]] | ||
| - | [[Category: | + | [[Category: Crystal structure]] |
| - | + | [[Category: Dna-binding domain]] | |
| - | [[Category: | + | [[Category: Dna-binding specificity]] |
| - | [[Category: | + | [[Category: Ets domain]] |
| - | [[Category: | + | [[Category: Winged helix-turn-helix]] |
| - | [[Category: | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:19:41 2008'' |
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:19, 2 May 2008
SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX
Overview
SAP-1 is a member of the Ets transcription factors and cooperates with SRF protein to activate transcription of the c-fos protooncogene. The crystal structures of the conserved ETS domain of SAP-1 bound to DNA sequences from the E74 and c-fos promoters reveal that a set of conserved residues contact a GGA core DNA sequence. Discrimination for sequences outside this core is mediated by DNA contacts from conserved and nonconserved protein residues and sequence-dependent DNA structural properties characteristic of A-form DNA structure. Comparison with the related PU.1/DNA and GABPalpha/beta/DNA complexes provides general insights into DNA discrimination between Ets proteins. Modeling studies of a SAP-1/SRF/DNA complex suggest that SRF may modulate SAP-1 binding to DNA by interacting with its ETS domain.
About this Structure
1BC7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins., Mo Y, Vaessen B, Johnston K, Marmorstein R, Mol Cell. 1998 Aug;2(2):201-12. PMID:9734357 Page seeded by OCA on Fri May 2 11:19:41 2008
