5h8s

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m (Protected "5h8s" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5h8s is ON HOLD
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==Structure of the human GluA2 LBD in complex with GNE3419==
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<StructureSection load='5h8s' size='340' side='right' caption='[[5h8s]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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Authors: Wallweber, H.J.A., Lupardus, P.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5h8s]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H8S FirstGlance]. <br>
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Description: Structure of the human GluA2 LBD in complex with GNE3419
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5YC:7-[[ETHYL(PHENYL)AMINO]METHYL]-2-METHYL-[1,3,4]THIADIAZOLO[3,2-A]PYRIMIDIN-5-ONE'>5YC</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5h8f|5h8f]], [[5h8h|5h8h]], [[5h8n|5h8n]], [[5h8q|5h8q]], [[5h8r|5h8r]]</td></tr>
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[[Category: Wallweber, H.J.A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h8s OCA], [http://pdbe.org/5h8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h8s RCSB], [http://www.ebi.ac.uk/pdbsum/5h8s PDBsum]</span></td></tr>
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[[Category: Lupardus, P.J]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GRIA2_HUMAN GRIA2_HUMAN]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:20614889</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Lupardus, P J]]
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[[Category: Wallweber, H J.A]]
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[[Category: Glun1]]
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[[Category: Glun2a]]
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[[Category: Nmda]]
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[[Category: Receptor]]
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[[Category: Transport protein]]

Revision as of 18:22, 26 February 2016

Structure of the human GluA2 LBD in complex with GNE3419

5h8s, resolution 1.70Å

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