1bcd

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[[Image:1bcd.jpg|left|200px]]
[[Image:1bcd.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1bcd |SIZE=350|CAPTION= <scene name='initialview01'>1bcd</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1bcd", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FMS:TRIFLUOROMETHANE+SULFONAMIDE'>FMS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1bcd| PDB=1bcd | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bcd OCA], [http://www.ebi.ac.uk/pdbsum/1bcd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bcd RCSB]</span>
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}}
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'''X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE'''
'''X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE'''
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[[Category: Hakansson, K.]]
[[Category: Hakansson, K.]]
[[Category: Liljas, A.]]
[[Category: Liljas, A.]]
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[[Category: lyase(oxo-acid)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:20:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:58:05 2008''
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Revision as of 08:20, 2 May 2008

Image:1bcd.jpg

Template:STRUCTURE 1bcd

X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE


Overview

It has recently been shown that aliphatic sulphonamides are good inhibitors of carbonic anhydrase (CA) provided that the pK of the sulphonamide is low. We have determined the structure of the complex between CAII and CF3SO2NH2 by X-ray crystallographic methods. The nitrogen of the sulphonamide is bound to the zinc ion of the enzyme in the usual manner. The other parts of the inhibitor show a different mode of binding from aromatic sulphonamides since the trifluoromethyl group is bound at the hydrophobic part of the active site instead of pointing out from the active site. It should be possible to design new inhibitors specific for the different isoenzymes, starting from the present structure.

About this Structure

1BCD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of a complex between carbonic anhydrase II and a new inhibitor, trifluoromethane sulphonamide., Hakansson K, Liljas A, FEBS Lett. 1994 Aug 22;350(2-3):319-22. PMID:8070585 Page seeded by OCA on Fri May 2 11:20:04 2008

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