This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
DNA ligase
From Proteopedia
| Line 1: | Line 1: | ||
| - | <StructureSection load='2hix' size=' | + | <StructureSection load='2hix' size='350' side='right' scene='DNA_ligase/Cv/1' caption='ATP-dependent DNA ligase complexed with ATP [[2hix]]'> |
__TOC__ | __TOC__ | ||
== Function == | == Function == | ||
| Line 17: | Line 17: | ||
== Structural highlights == | == Structural highlights == | ||
| - | LigD contains several domains: | + | Human LigD IV contains several domains: DNA-binding domain (residues 1-240); adenylation domain (residues 268-405) and the ca. 100 amino acid long BRCT motifs (residues 654-911). In the ATP-dependent LigD the ATP binds between 2 symmetry related LigD molecules. |
</StructureSection> | </StructureSection> | ||
Revision as of 13:27, 31 December 2015
| |||||||||||
3D Structures of DNA ligase
Updated on 31-December-2015
REFERENCES
Elevated expression of DNA ligase I in human cancers., Sun DY, Urrabaz R, Nguyen M, Marty J, Stringer S, Cruz E, Medina-Gundrum L, Weitman S., Clinical Cancer Research. 2001; 7(12):4143-4148.
Replication failure, genome instability, and increased cancer susceptibility in mice with a point mutation in the DNA ligase I gene., Harrison C, Ketchen AM, Redhead NJ, O'Sullivan MJ, Melton DW., Cancer Research. 2002; 62(14):4065-4074.
- Created with the participation of Audrey Kuan.
