Dual specificity protein kinase

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{{STRUCTURE_2x9e| PDB=2x9e | SIZE=400| SCENE= |right|CAPTION=Dual specificity protein kinase TTK kinase domain complex with inhibitor, [[2x9e]] }}
{{STRUCTURE_2x9e| PDB=2x9e | SIZE=400| SCENE= |right|CAPTION=Dual specificity protein kinase TTK kinase domain complex with inhibitor, [[2x9e]] }}
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== Function ==
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'''Dual specificity protein kinases''' are kinases which act as both tyrosine kinase and serine/threonine kinase. '''CLK1''' phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing. The dual specificity protein kinase '''TTK''' contains tetra-trico-peptide repeat domain (TPR) which serves as interaction domain between proteins.<ref>PMID:9779990</ref>
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'''Dual specificity protein kinases''' are kinases which act as both tyrosine kinase and serine/threonine kinase. '''CLK1''' phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing.
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== Structural highlights ==
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The dual specificity protein kinase '''TTK''' contains tetratricopeptide repeat domain (TPR) which serves as interaction domain between proteins. The TPR domain is a helical 34 amino acid motif which is found in several copies in a protein which fold together forming a protein-protein binding domain.<ref>PMID:9779990</ref>
==3D structures of dual specificity protein kinase==
==3D structures of dual specificity protein kinase==

Revision as of 15:47, 3 January 2016

Template:STRUCTURE 2x9e

Contents

Function

Dual specificity protein kinases are kinases which act as both tyrosine kinase and serine/threonine kinase. CLK1 phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing.

Structural highlights

The dual specificity protein kinase TTK contains tetratricopeptide repeat domain (TPR) which serves as interaction domain between proteins. The TPR domain is a helical 34 amino acid motif which is found in several copies in a protein which fold together forming a protein-protein binding domain.[1]

3D structures of dual specificity protein kinase

Updated on 03-January-2016

References

  1. ↑ Dhanasekaran N, Premkumar Reddy E. Signaling by dual specificity kinases. Oncogene. 1998 Sep 17;17(11 Reviews):1447-55. PMID:9779990 doi:http://dx.doi.org/10.1038/sj.onc.1202251

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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