Tubulin
From Proteopedia
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{{STRUCTURE_1z5w| PDB=1z5w | SIZE=350| SCENE=Tubulin/Cv/1 |right|CAPTION= γ-tubulin complex with GTP and Mg+2 ion (green), [[1z5w]] }} | {{STRUCTURE_1z5w| PDB=1z5w | SIZE=350| SCENE=Tubulin/Cv/1 |right|CAPTION= γ-tubulin complex with GTP and Mg+2 ion (green), [[1z5w]] }} | ||
| + | == Function == | ||
[[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of '''α-tubulin''' (TUBA) and '''β-tubulin''' (TUBB) bound to GTP. See also [[Beta tubulin]]. '''γ-tubulin''' (TUBG) is part of the nucleation of microtubules. Human TUB contains several numbered subtypes. '''FtsZ''' (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB. See also [[Beta tubulin]]. | [[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of '''α-tubulin''' (TUBA) and '''β-tubulin''' (TUBB) bound to GTP. See also [[Beta tubulin]]. '''γ-tubulin''' (TUBG) is part of the nucleation of microtubules. Human TUB contains several numbered subtypes. '''FtsZ''' (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB. See also [[Beta tubulin]]. | ||
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| + | == Relevance == | ||
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| + | The chemotherapeutic drug Taxol interacts with TUBB. See [[Molecular Playground/Taxol]]. | ||
== 3D Structures of Tubulin == | == 3D Structures of Tubulin == | ||
Revision as of 12:11, 15 February 2016
Function
Tubulin (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of α-tubulin (TUBA) and β-tubulin (TUBB) bound to GTP. See also Beta tubulin. γ-tubulin (TUBG) is part of the nucleation of microtubules. Human TUB contains several numbered subtypes. FtsZ (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB. See also Beta tubulin.
Relevance
The chemotherapeutic drug Taxol interacts with TUBB. See Molecular Playground/Taxol.
3D Structures of Tubulin
Updated on 15-February-2016
