CCL2
From Proteopedia
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<StructureSection load='1dok' size='340' side='right' caption='Monocyte chemoattractant protein 1 complex with sulfate (PDB code [[1dok]])' scene=''> | <StructureSection load='1dok' size='340' side='right' caption='Monocyte chemoattractant protein 1 complex with sulfate (PDB code [[1dok]])' scene=''> | ||
| - | The''' chemokine (C-C motif) ligand''' | + | == Function == |
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| + | '''Monocyte chemoattractant protein''' (MCP) belongs to the superfamily of chemokines, which are proteins involved in immunoregulatory and inflammatory processes. The superfamily can be subdivided into 4 smaller groups, depending on the N-ter arangment of the cysteines. The MCP-1<ref>PMID:8170963</ref> is also known as '''chemokine (C-C motif) ligand''' or '''CCL2''' or: | ||
- small inducible cytokine A2 (SCYA2) | - small inducible cytokine A2 (SCYA2) | ||
- MCAF | - MCAF | ||
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- GDCF-2 | - GDCF-2 | ||
- HC11. | - HC11. | ||
| - | == Function == | ||
== Disease == | == Disease == | ||
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| + | CCL2 is implicated in several diseases like psoriasis, rheumatoid arthritis and atherosclerosis. | ||
== Relevance == | == Relevance == | ||
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| + | CCL2 is overexpressed in epilepsy, brain ischemia, Alzheimer's disease, EAE and traumatic brain injury. | ||
== Structural highlights == | == Structural highlights == | ||
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| + | CCL2 is part of the C-C motif group because of the covalent bond made between 2 of the 4 cysteines of the Nter domain. | ||
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| + | </StructureSection> | ||
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| + | ==3D structures of 6-aminohexanoate-dimer hydrolase== | ||
| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| + | * Monocyte chemoattractant protein 1 | ||
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| + | **[[1dok]], [[1dol]] – hMCP-1 (mutant) - human<br /> | ||
| + | **[[3ifd]] – hMCP-1 <br /> | ||
| + | **[[1dom]], [[1don]] – hMCP-1 - NMR<br /> | ||
| + | **[[1ml0]], [[2nz1]] – hMCP-1 (mutant) + M3 protein<br /> | ||
| + | **[[2bdn]] – hMCP-1 + antibody<br /> | ||
| + | **[[4dn4]] – hMCP-1 (mutant) + antibody<br /> | ||
| + | **[[4zk9]] – hMCP-1 + chemokine binding protein<br /> | ||
| + | **[[4r8i]] – hMCP-1 + RNA<br /> | ||
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| + | * Monocyte chemoattractant protein 2 | ||
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| + | **[[1esr]] – hMCP-2 (mutant) <br /> | ||
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| + | * Monocyte chemoattractant protein 3 | ||
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| + | **[[1ncv]], [[1bo0]] – hMCP-3 - NMR<br /> | ||
| + | **[[4zkc]] – hMCP-3 + chemokine binding protein<br /> | ||
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| + | * Monocyte chemoattractant protein 4 | ||
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| + | **[[2ra4]] – hMCP-4 <br /> | ||
| + | }} | ||
== References == | == References == | ||
https://fr.wikipedia.org/wiki/CCL2 | https://fr.wikipedia.org/wiki/CCL2 | ||
Revision as of 14:33, 5 January 2016
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3D structures of 6-aminohexanoate-dimer hydrolase
Updated on 05-January-2016
References
https://fr.wikipedia.org/wiki/CCL2 http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1DOK http://www.uniprot.org/uniprot/P13500#interaction
- ↑ Carr MW, Roth SJ, Luther E, Rose SS, Springer TA. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3652-6. PMID:8170963
