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CCL2

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Current revision (19:37, 5 January 2016) (edit) (undo)
 
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<StructureSection load='1dok' size='340' side='right' caption='Monocyte chemoattractant protein 1 complex with sulfate (PDB code [[1dok]])' scene=''>
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#REDIRECT [[Monocyte chemoattractant protein]]
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== Function ==
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'''Monocyte chemoattractant protein''' (MCP) belongs to the superfamily of chemokines, which are proteins involved in immunoregulatory and inflammatory processes. The superfamily can be subdivided into 4 smaller groups, depending on the N-ter arangment of the cysteines. The MCP-1<ref>PMID:8170963</ref> is also known as '''chemokine (C-C motif) ligand''' or '''CCL2''' or:
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- small inducible cytokine A2 (SCYA2)
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- MCAF
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- GDCF-2
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- SMC-CF
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- HSMCR30
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- MGC9434
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- GDCF-2
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- HC11.
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== Disease ==
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CCL2 is implicated in several diseases like psoriasis, rheumatoid arthritis and atherosclerosis.
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== Relevance ==
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CCL2 is overexpressed in epilepsy, brain ischemia, Alzheimer's disease, EAE and traumatic brain injury.
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== Structural highlights ==
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CCL2 is part of the C-C motif group because of the covalent bond made between 2 of the 4 cysteines of the N terminal domain.<ref>PMID:8989326</ref>
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</StructureSection>
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==3D structures of 6-aminohexanoate-dimer hydrolase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* Monocyte chemoattractant protein 1
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**[[1dok]], [[1dol]] – hMCP-1 (mutant) - human<br />
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**[[3ifd]] – hMCP-1 <br />
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**[[1dom]], [[1don]] – hMCP-1 - NMR<br />
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**[[1ml0]], [[2nz1]] – hMCP-1 (mutant) + M3 protein<br />
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**[[2bdn]] – hMCP-1 + antibody<br />
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**[[4dn4]] – hMCP-1 (mutant) + antibody<br />
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**[[4zk9]] – hMCP-1 + chemokine binding protein<br />
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**[[4r8i]] – hMCP-1 + RNA<br />
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* Monocyte chemoattractant protein 2
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**[[1esr]] – hMCP-2 (mutant) <br />
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* Monocyte chemoattractant protein 3
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**[[1ncv]], [[1bo0]] – hMCP-3 - NMR<br />
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**[[4zkc]] – hMCP-3 + chemokine binding protein<br />
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* Monocyte chemoattractant protein 4
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**[[2ra4]] – hMCP-4 <br />
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}}
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== References ==
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https://fr.wikipedia.org/wiki/CCL2
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http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1DOK
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http://www.uniprot.org/uniprot/P13500#interaction
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<references/>
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Current revision

  1. REDIRECT Monocyte chemoattractant protein

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Coline Perrin, Alexander Berchansky

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