Cyclin-dependent kinase regulatory subunit

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'''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in <scene name='71/715441/Pdb4yc6/1'>pdb 4yc6</scene> where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red. CKS1 is essential for CDK5 functioning in neuronal differentiation.<ref>PMID:8491379</ref>
'''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in <scene name='71/715441/Pdb4yc6/1'>pdb 4yc6</scene> where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red. CKS1 is essential for CDK5 functioning in neuronal differentiation.<ref>PMID:8491379</ref>
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== Disease ==
 
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== Relevance ==
 
== Structural highlights ==
== Structural highlights ==

Revision as of 17:37, 5 January 2016

Human CKS-1 complex with phosphate (PDB code 1dks)

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3D Structures of cyclin-dependent kinase regulatory subunit

Updated on 05-January-2016

References

  1. ↑ Tang Y, Reed SI. The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae. Genes Dev. 1993 May;7(5):822-32. PMID:8491379

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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