1bec

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[[Image:1bec.jpg|left|200px]]
[[Image:1bec.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bec OCA], [http://www.ebi.ac.uk/pdbsum/1bec PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bec RCSB]</span>
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'''BETA CHAIN OF A T CELL ANTIGEN RECEPTOR'''
'''BETA CHAIN OF A T CELL ANTIGEN RECEPTOR'''
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[[Category: Karjalainen, K.]]
[[Category: Karjalainen, K.]]
[[Category: Mariuzza, R A.]]
[[Category: Mariuzza, R A.]]
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[[Category: t cell receptor]]
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[[Category: T cell receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:24:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:59:11 2008''
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Revision as of 08:24, 2 May 2008

Template:STRUCTURE 1bec

BETA CHAIN OF A T CELL ANTIGEN RECEPTOR


Overview

The crystal structure of the extracellular portion of the beta chain of a murine T cell antigen receptor (TCR), determined at a resolution of 1.7 angstroms, shows structural homology to immunoglobulins. The structure of the first and second hypervariable loops suggested that, in general, they adopt more restricted sets of conformations in TCR beta chains than those found in immunoglobulins; the third hypervariable loop had certain structural characteristics in common with those of immunoglobulin heavy chain variable domains. The variable and constant domains were in close contact, presumably restricting the flexibility of the beta chain. This may facilitate signal transduction from the TCR to the associated CD3 molecules in the TCR-CD3 complex.

About this Structure

1BEC is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the beta chain of a T cell antigen receptor., Bentley GA, Boulot G, Karjalainen K, Mariuzza RA, Science. 1995 Mar 31;267(5206):1984-7. PMID:7701320 Page seeded by OCA on Fri May 2 11:24:22 2008

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