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Insulin receptor

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'''Insulin receptor''' (IR) is a transmembrane receptor activated by insulin, IGF-I and IGF-II. IR is important for the regulation of glucose homeostasis and its malfunction can cause diabetics and cancer. The IR is a dimer where each monomer contains 8 distinct domains. The β-chain contains a tyrosine kinase catalytic domain (TK).<br />
'''Insulin receptor''' (IR) is a transmembrane receptor activated by insulin, IGF-I and IGF-II. IR is important for the regulation of glucose homeostasis and its malfunction can cause diabetics and cancer. The IR is a dimer where each monomer contains 8 distinct domains. The β-chain contains a tyrosine kinase catalytic domain (TK).<br />
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See also [[Insulin Receptor kinase domain (hebrew)]].
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See also [[Insulin Receptor - kinase domain (hebrew)]].
==3D structures of insulin receptor==
==3D structures of insulin receptor==

Revision as of 12:44, 6 January 2016

Structure of human insulin receptor tyrosine kinase catalytic domain complex with insulin receptor substrate 2 peptide (green), Mg+2 ion (green) and ATP (stick model) (PDB entry 3bu5)

Drag the structure with the mouse to rotate
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