Regulator of G protein signaling
From Proteopedia
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RGS proteins whose activity was tested are colored by their GAP activity, RGS proteins with high GAP activity (green), RGS proteins with low but discernible activities (purple) and RGS2 had no measurable activity (red). | RGS proteins whose activity was tested are colored by their GAP activity, RGS proteins with high GAP activity (green), RGS proteins with low but discernible activities (purple) and RGS2 had no measurable activity (red). | ||
<ref name="Mickey2011">PMID: 21685921</ref> | <ref name="Mickey2011">PMID: 21685921</ref> | ||
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+ | == Various RGS functions == | ||
+ | |||
+ | *'''RGS1''' selectively regulates gut T cell trafficking and colitis potential<ref>PMID:21795595</ref>.<br /> | ||
+ | *'''RGS3''' is associated with glioma cell motility<ref>PMID:15055445</ref>.<br /> | ||
+ | *'''RGS4''' is associated with schizophrenia<ref>PMID:15274033</ref>.<br /> | ||
+ | *'''RGS6''' promotes anxiety and depression<ref>PMID:24421401</ref>.<br /> | ||
+ | *'''RGS410'' negatively regulates cardia remodeling<ref>PMID:26573707</ref>.<br /> | ||
+ | *'''RGS14''' is an selective Hras effector <ref>PMID:19319189</ref>.<br /> | ||
== RGS4 Structural highlights == | == RGS4 Structural highlights == |
Revision as of 09:10, 3 August 2016
Regulator of G protein signaling (RGS) interactions with G proteins – RGS4-Gαi as a model structure.
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3D structures of regulator of G-protein signalling
Updated on 03-August-2016
References
- ↑ Milligan G, Kostenis E. Heterotrimeric G-proteins: a short history. Br J Pharmacol. 2006 Jan;147 Suppl 1:S46-55. PMID:16402120 doi:http://dx.doi.org/10.1038/sj.bjp.0706405
- ↑ 2.0 2.1 2.2 Kosloff M, Travis AM, Bosch DE, Siderovski DP, Arshavsky VY. Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions. Nat Struct Mol Biol. 2011 Jun 19;18(7):846-53. doi: 10.1038/nsmb.2068. PMID:21685921 doi:http://dx.doi.org/10.1038/nsmb.2068
- ↑ Gibbons DL, Abeler-Dorner L, Raine T, Hwang IY, Jandke A, Wencker M, Deban L, Rudd CE, Irving PM, Kehrl JH, Hayday AC. Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential. J Immunol. 2011 Sep 1;187(5):2067-71. doi: 10.4049/jimmunol.1100833. Epub 2011, Jul 27. PMID:21795595 doi:http://dx.doi.org/10.4049/jimmunol.1100833
- ↑ Tatenhorst L, Senner V, Puttmann S, Paulus W. Regulators of G-protein signaling 3 and 4 (RGS3, RGS4) are associated with glioma cell motility. J Neuropathol Exp Neurol. 2004 Mar;63(3):210-22. PMID:15055445
- ↑ Chen X, Dunham C, Kendler S, Wang X, O'Neill FA, Walsh D, Kendler KS. Regulator of G-protein signaling 4 (RGS4) gene is associated with schizophrenia in Irish high density families. Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129B(1):23-6. PMID:15274033 doi:http://dx.doi.org/10.1002/ajmg.b.30078
- ↑ Stewart A, Maity B, Wunsch AM, Meng F, Wu Q, Wemmie JA, Fisher RA. Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis. FASEB J. 2014 Apr;28(4):1735-44. doi: 10.1096/fj.13-235648. Epub 2014 Jan 13. PMID:24421401 doi:http://dx.doi.org/10.1096/fj.13-235648
- ↑ Miao R, Lu Y, Xing X, Li Y, Huang Z, Zhong H, Huang Y, Chen AF, Tang X, Li H, Cai J, Yuan H. Regulator of G-Protein Signaling 10 Negatively Regulates Cardiac Remodeling by Blocking Mitogen-Activated Protein Kinase-Extracellular Signal-Regulated Protein Kinase 1/2 Signaling. Hypertension. 2016 Jan;67(1):86-98. doi: 10.1161/HYPERTENSIONAHA.115.05957. Epub , 2015 Nov 16. PMID:26573707 doi:http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.05957
- ↑ Willard FS, Willard MD, Kimple AJ, Soundararajan M, Oestreich EA, Li X, Sowa NA, Kimple RJ, Doyle DA, Der CJ, Zylka MJ, Snider WD, Siderovski DP. Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. PLoS One. 2009;4(3):e4884. doi: 10.1371/journal.pone.0004884. Epub 2009 Mar 25. PMID:19319189 doi:http://dx.doi.org/10.1371/journal.pone.0004884
- ↑ 9.0 9.1 Tesmer JJ, Berman DM, Gilman AG, Sprang SR. Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis. Cell. 1997 Apr 18;89(2):251-61. PMID:9108480
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