5f98

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'''Unreleased structure'''
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==Structural basis for m7G recognition and 2-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I==
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<StructureSection load='5f98' size='340' side='right' caption='[[5f98]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
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The entry 5f98 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5f98]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F98 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F98 FirstGlance]. <br>
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Authors: Wang, C., Marcotrigiano, J., Miller, M.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tmi|3tmi]], [[5f9f|5f9f]], [[5f9h|5f9h]]</td></tr>
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Description: Structural basis for m7G recognition and 2-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f98 OCA], [http://pdbe.org/5f98 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f98 RCSB], [http://www.ebi.ac.uk/pdbsum/5f98 PDBsum]</span></td></tr>
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[[Category: Wang, C]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/DDX58_HUMAN DDX58_HUMAN]] Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.<ref>PMID:15208624</ref> <ref>PMID:16125763</ref> <ref>PMID:15708988</ref> <ref>PMID:16153868</ref> <ref>PMID:16127453</ref> <ref>PMID:17190814</ref> <ref>PMID:18636086</ref> <ref>PMID:19631370</ref> <ref>PMID:19576794</ref> <ref>PMID:19122199</ref> <ref>PMID:19211564</ref> <ref>PMID:19609254</ref> <ref>PMID:21742966</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: RNA helicase]]
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[[Category: Jiang, F]]
[[Category: Marcotrigiano, J]]
[[Category: Marcotrigiano, J]]
[[Category: Miller, M]]
[[Category: Miller, M]]
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[[Category: Wang, C]]
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[[Category: Capped rna]]
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[[Category: Complex]]
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[[Category: Hydrolase-rna complex]]
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[[Category: Innate immunity]]
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[[Category: Rig-i]]
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[[Category: Self versus non-self]]

Revision as of 20:35, 13 January 2016

Structural basis for m7G recognition and 2-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I

5f98, resolution 3.28Å

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