5h9m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5h9m" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5h9m is ON HOLD
+
==Crystal structure of siah2 SBD domain==
-
 
+
<StructureSection load='5h9m' size='340' side='right' caption='[[5h9m]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
-
Authors: Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5h9m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H9M FirstGlance]. <br>
-
Description: Crystal structure of siah2 SBD domain
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9m OCA], [http://pdbe.org/5h9m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h9m RCSB], [http://www.ebi.ac.uk/pdbsum/5h9m PDBsum]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/SIAH2_HUMAN SIAH2_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not. Promotes monoubiquitination of SNCA.<ref>PMID:11483518</ref> <ref>PMID:12411493</ref> <ref>PMID:19224863</ref> <ref>PMID:22878263</ref> <ref>PMID:9334332</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Arrowsmith, C H]]
 +
[[Category: Bountra, C]]
[[Category: Dong, A]]
[[Category: Dong, A]]
-
[[Category: Walker, J.R]]
+
[[Category: Edwards, A M]]
-
[[Category: Bountra, C]]
+
[[Category: Structural genomic]]
-
[[Category: Arrowsmith, C.H]]
+
[[Category: Tong, Y]]
[[Category: Tong, Y]]
-
[[Category: Edwards, A.M]]
+
[[Category: Walker, J R]]
-
[[Category: Structural Genomics Consortium (Sgc)]]
+
[[Category: Zhang, Q]]
[[Category: Zhang, Q]]
 +
[[Category: Ligase]]
 +
[[Category: Sbd]]
 +
[[Category: Sgc]]
 +
[[Category: Siah2]]

Revision as of 02:57, 21 February 2016

Crystal structure of siah2 SBD domain

5h9m, resolution 1.76Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5h9m"
Personal tools