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5hbc

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'''Unreleased structure'''
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==Intermediate structure of iron-saturated C-lobe of bovine lactoferrin at 2.79 Angstrom resolution indicates the softening of iron coordination==
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<StructureSection load='5hbc' size='340' side='right' caption='[[5hbc]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
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The entry 5hbc is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5hbc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HBC FirstGlance]. <br>
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Authors: Singh, A., Rastogi, N., Singh, P.K., Tyagi, T.K., Kaur, P., Sharma, S., Singh, T.P.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4oqo|4oqo]]</td></tr>
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Description: Intermediate structure of iron-saturated C-lobe of bovine lactoferrin at 2.79 Angstrom resolution indicates the softening of iron coordination
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hbc OCA], [http://pdbe.org/5hbc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hbc RCSB], [http://www.ebi.ac.uk/pdbsum/5hbc PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Singh, P.K]]
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== Function ==
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[[Category: Singh, T.P]]
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[[http://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bos taurus]]
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[[Category: Kaur, P]]
[[Category: Rastogi, N]]
[[Category: Rastogi, N]]
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[[Category: Singh, A]]
 
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[[Category: Tyagi, T.K]]
 
[[Category: Sharma, S]]
[[Category: Sharma, S]]
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[[Category: Kaur, P]]
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[[Category: Singh, A]]
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[[Category: Singh, P K]]
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[[Category: Singh, T P]]
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[[Category: Tyagi, T K]]
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[[Category: C-lobe]]
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[[Category: Hydrolase]]
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[[Category: Lactoferrin]]

Revision as of 17:27, 20 January 2016

Intermediate structure of iron-saturated C-lobe of bovine lactoferrin at 2.79 Angstrom resolution indicates the softening of iron coordination

5hbc, resolution 2.79Å

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