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Met repressor

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[[Image:1mjo.png|left|200px|thumb|EcMR (mutant) complex with corepressor SAM and DNA [[2eyi]]]]
 
{{STRUCTURE_1mjo| PDB=1mjo | SIZE=400| SCENE= |right|CAPTION=EcMR (mutant) complex with corepressor SAM Ca+2 ion (green) and DNA [[1mjo]] }}
{{STRUCTURE_1mjo| PDB=1mjo | SIZE=400| SCENE= |right|CAPTION=EcMR (mutant) complex with corepressor SAM Ca+2 ion (green) and DNA [[1mjo]] }}
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== Function ==
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'''Met repressor''' (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The coreppressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis<ref>PMID:11696548</ref>. For additional details see<br />
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'''Met repressor''' (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The corepressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis. For additional details see<br />
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[[Taylor met repressor]]<br />
[[Taylor met repressor]]<br />
[[Joe Granger Methionine Repressor: Escherichia coli]].
[[Joe Granger Methionine Repressor: Escherichia coli]].
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[[1mjl]], [[1mjp]] – EcMR (mutant) + SAM<br />
[[1mjl]], [[1mjp]] – EcMR (mutant) + SAM<br />
[[1mj2]], [[1mjo]], [[1mjq]] – EcMR (mutant) + SAM + DNA<br />
[[1mj2]], [[1mjo]], [[1mjq]] – EcMR (mutant) + SAM + DNA<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:37, 20 April 2016

Template:STRUCTURE 1mjo

Function

Met repressor (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The coreppressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis[1]. For additional details see
Taylor met repressor
Joe Granger Methionine Repressor: Escherichia coli.

3D Structures of Met repressor

Updated on 20-April-2016

1cmb – EcMR – Escherichia coli
1mjk – EcMR (mutant)
1cma – EcMR + DNA
1mjm – EcMR (mutant) + DNA
1cmc – EcMR + SAM
1mjl, 1mjp – EcMR (mutant) + SAM
1mj2, 1mjo, 1mjq – EcMR (mutant) + SAM + DNA

References

  1. ↑ Friedrich R, Fuentes-Prior P, Ong E, Coombs G, Hunter M, Oehler R, Pierson D, Gonzalez R, Huber R, Bode W, Madison EL. Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. J Biol Chem. 2002 Jan 18;277(3):2160-8. Epub 2001 Nov 5. PMID:11696548 doi:10.1074/jbc.M109830200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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