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1bgw

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[[Image:1bgw.gif|left|200px]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgw OCA], [http://www.ebi.ac.uk/pdbsum/1bgw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bgw RCSB]</span>
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'''TOPOISOMERASE RESIDUES 410-1202,'''
'''TOPOISOMERASE RESIDUES 410-1202,'''
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[[Category: Harrison, S C.]]
[[Category: Harrison, S C.]]
[[Category: Wang, J C.]]
[[Category: Wang, J C.]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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[[Category: phosphorylated nuclear protein]]
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[[Category: Phosphorylated nuclear protein]]
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[[Category: topoisomerase]]
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[[Category: Topoisomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:29:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:00:40 2008''
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Revision as of 08:29, 2 May 2008

Image:1bgw.gif

Template:STRUCTURE 1bgw

TOPOISOMERASE RESIDUES 410-1202,


Overview

The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws.

About this Structure

1BGW is a Single protein structure of sequence from Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1BGW with [Topoisomerases]. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of DNA topoisomerase II., Berger JM, Gamblin SJ, Harrison SC, Wang JC, Nature. 1996 Jan 18;379(6562):225-32. PMID:8538787 Page seeded by OCA on Fri May 2 11:29:46 2008

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